Translation of "Debilitating" in Japanese

Cancer patients often have to deal with debilitating bouts of nausea.

癌患者は心をくじく吐き気の発作にしばしば対峙しなければならない。

All of this means that depression can be as debilitating as a physical obstacle.

うつ病は 杖をつかなければ歩けないほど