Translation of "それが問題？" in English

それが問題？

Is that a problem?

それが 問題です

That's a challenge,

それが問題なのよ。

That's the problem.

「それが問題になるのか？」

"Does this matter?"

生きるか死ぬか、それが問題だ。

- To be or not to be, that is the question.
- To be, or not to be: that is the question.

生殖腺以外でそれが問題になるのか？

Does it matter outside the reproductive tract?